1802Prevalence of KPC-possessing Klebsiella pneumoniae in New York City: Have We Turned the Corner?
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چکیده
1802. Prevalence of KPC-possessing Klebsiella pneumoniae in New York City: Have We Turned the Corner? Marie Abdallah, MD; Olawole Olafisoye, MD; Christopher Cortes, MD; Clayton Charles, MD; Carl Urban, PhD; David Landman, MD; John Quale, MD; Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY; Infectious Diseases, New York Hospital Queens, Flushing, NY; Medicine, SUNY Downstate Medical Center, Brooklyn, NY; Infectious Disease, New York Hospital Queens, Flushing, NY
منابع مشابه
Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection.
Among 257 isolates of Klebsiella pneumoniae collected in Brooklyn, NY, 24% were found to possess bla(KPC). Clinical microbiology laboratories that used automated broth microdilution systems reported 15% of the KPC-possessing isolates as susceptible to imipenem. The imipenem MIC was found to be markedly affected by the inoculum. For accurate detection of KPC-possessing K. pneumoniae, particular ...
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Carbapenem-resistant Klebsiella strains carrying Klebsiella pneumoniae carbapenemases (KPC) are endemic to New York City and are spreading across the United States and internationally. Recent studies have indicated that the KPC structural gene is located on a 10-kb plasmid-borne element designated Tn4401. Fourteen Klebsiella pneumoniae strains and one Klebsiella oxytoca strain isolated at a New...
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OBJECTIVES Carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa are endemic in many medical centres. Because therapeutic options are limited, understanding the epidemiology and controlling the spread of these pathogens are of paramount importance. METHODS Isolates of K. pneumoniae, A. baumannii and P. aeruginosa were collected from 14 hospitals in New...
متن کاملMultiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variants.
Carbapenem resistance mediated by plasmid-borne Klebsiella pneumoniae carbapenemases (KPC) is an emerging problem of significant clinical importance in Gram-negative bacteria. Multiple KPC gene variants (bla(KPC)) have been reported, with KPC-2 (bla(KPC-2)) and KPC-3 (bla(KPC-3)) associated with epidemic outbreaks in New York City and various international settings. Here, we describe the develo...
متن کاملPlasmid comparison and molecular analysis of Klebsiella pneumoniae harbouring bla(KPC) from New York City and Toronto.
OBJECTIVES This study examined Klebsiella pneumoniae clinical isolates and their bla(KPC) plasmids to determine potential relatedness of the isolates and their plasmids harbouring carbapenem resistance mechanisms. METHODS K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae from New York City (NYC) (n = 19) and Toronto (n = 2) were typed by PFGE and multilocus sequence typing (MLST). bla...
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